OPIOID-INDUCED CONSTIPATION IN PALLIATIVE CARE: STATE OF THE ART

• Published in: Revista de pesquisa, cuidado é fundamental Vol. 12; pp. 1116 - 1124
• Main Authors: da Silva, Geslaney Reis, Freitas, Erlania do Carmo, da Silva, Rudval Souza, Milagres, Maria Patrícia, Boery, Rita Narriman Silva de Oliveira
• Format: Journal Article
• Language: English
• Published: Rio de Janeiro Universidade Federal do Estado do Rio de Janeiro, Programa de Pós-Graduação em Enfermagem 01.01.2020
• Subjects: Cancer therapies; Chronic illnesses; Clinical trials; Constipation; Fentanyl; Health sciences; Libraries; Literature reviews; Meta-analysis; Morphine; Narcotics; Pain; Palliative care
• ISSN: 2175-5361
• DOI: 10.9789/2175-5361.rpcfo.vl2.8008

There were included articles published in peer-reviewed journals using methodologies with randomized clinical trials with children and adults, case studies and systematic reviews with meta-analysis published from 2013 to 2017, in English, Spanish and Portuguese, addressing studies with palliative care patients who use morphine or other opioids as therapy for moderate to chronic pain and who have developed opioid-induced constipation. Guidelines were excluded, articles that had conflicts of interest and did not have a clinical trial, articles that had restricted access in which the main authors did not respond to the requested electronic correspondences to date (n=5), articles with animal research; bibliographic reviews without meta-analysis; articles dealing with chronic opioid pain but without palliative care; and research that did not match the outcome of the research and did not answer the guiding question proposed. [...]117 articles were found in the research databases. Other researchers20 performed a clinical trial with 1,147 cancer patients receiving opioids (morphine, oxycodone, and fentanyl) and observed a reduction in glomerular filtration rate.