Homoisoflavonoids: isolation, chemical synthesis strategies and biological activities

Homoisoflavonoids are important subcategory of flavonoids and present in wide range of plant families. [...]date approximately 300 homoisoflavonoids have been identified and evaluated for various biological activities such as anti-cancer, anti-diabetics, anti-infective, anti-inflammatory anti-oxidan...

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Bibliographic Details
Published inJournal of pharmaceutical sciences and research Vol. 12; no. 8; pp. 1046 - 1055
Main Authors Kumar, Vanktesh, Nayak, Surendra Kumar
Format Journal Article
LanguageEnglish
Published Cuddalore Journal of Pharmaceutical Sciences and Research 01.08.2020
Subjects
Acids
Carbon
Chemical synthesis
Chromatography
Flavonoids
Methods
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Summary:Homoisoflavonoids are important subcategory of flavonoids and present in wide range of plant families. [...]date approximately 300 homoisoflavonoids have been identified and evaluated for various biological activities such as anti-cancer, anti-diabetics, anti-infective, anti-inflammatory anti-oxidant etc. Dominating homoisoflavonoids exhibit stereoisomerism thus isolation of a single isomer is tedious process, however, some recent advances has been made in their extraction and isolation. [...]the low concentration of homoisoflavonoids in plants appreciated their chemical synthesis by different methods. The second method uses the reflux reaction of benzochromanone (16) with the substituted aromatic aldehyde (17) using 10% sodium hydroxide (aqueous NaOH) in catalytic amount can lead to formation of the HIFs. [...]of all this substituted HIFs(30)can be obtained at the end of reaction.
ISSN:0975-1459