Synthesis and Antibacterial Activity of NewOxadiazolylbenzodioxane Derivatives

Reactions of 5-(1,4-benzodioxan-2-yl)-1,3,4-oxadiazole-2-thiol with N-substituted chloroacetamides gave a series of the corresponding derivatives at the sulfur atom. Addition reactions of 5-(1,4-benzodioxan-2-yl)-1,3,4-oxadiazole-2-thiol to the C=C double bond of acrylonitrile, acrylamide, and ethyl...

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Bibliographic Details
Published inRussian journal of organic chemistry Vol. 56; no. 3; pp. 385 - 389
Main Authors Avagyan, A S, Vardanyan, S O, Sargsyan, A B, Aghekyan, A A, Panosyan, H A, Paronikyan, R V, Stepanyan, H M, Muradyan, R E
Format Journal Article
LanguageEnglish
Published New York Springer Nature B.V 01.01.2020
Subjects
Acrylamide
Derivatives
Morpholine
Organic chemistry
Piperidine
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Summary:Reactions of 5-(1,4-benzodioxan-2-yl)-1,3,4-oxadiazole-2-thiol with N-substituted chloroacetamides gave a series of the corresponding derivatives at the sulfur atom. Addition reactions of 5-(1,4-benzodioxan-2-yl)-1,3,4-oxadiazole-2-thiol to the C=C double bond of acrylonitrile, acrylamide, and ethyl acrylate, as well as Mannich condensation with morpholine and piperidine, were studied. The synthesized compounds were evaluated for their antibacterial activity.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428020030033