Effects of Vaping on Periodontium - A Review

• Published in: Journal of Advanced Medical and Dental Sciences Research Vol. 8; no. 2; pp. 69 - 72
• Main Authors: Kazi, Shazia, Khader, Anas Abdul, Sheth, Ami Mayurkumar, Khader, Mohasin Abdul, Javali, Mukhatar Ahmed, Hinge, Arundhati Pramod, Pandey, Pritee Rajkumar
• Format: Journal Article
• Language: English
• Published: Amritsar Journal of Advanced Medical and Dental Sciences Research (JAMDSR) 01.02.2020
• Subjects: Advanced glycosylation end products; Aerosols; Carbonyl compounds; Carbonyls; Carboxylation; Cigarettes; Cytokines; Damage; Deoxyribonucleic acid; Disease; DNA; DNA damage; Electronic cigarettes; Epithelium; Fibroblasts; Flavorings; Glycosylation; Inflammation; Ligaments; Nicotine; Oral cavity; Oral hygiene; Oxidative stress; Pathogenesis; Periodontal ligament; Periodontium; Proteins; Senescence; Smoking; Smoking cessation; Stem cells; Stress; Tobacco; Transplants & implants; Vaping
• ISSN: 2321-9599
• DOI: 10.21276/jamdsr

The electronic-cigarettes (e-cigs) represent a remarkable and increasing proportion of the tobacco product consumption, which can pose an oral health concern. Due to the protein carboxylation , oxidative/carbonyl stress is an important factor in causing the inflammation and the DNA damage. This will lead to the stress-induced premature senescence i.e, a state of irreversible growth arrest which re-enforces chronic inflammation in the gingival epithelium, which as a result may contribute to the pathogenesis of several oral diseases. This article describes the effects of e-cigs with the flavorings and its effects leading to an increased oxidative/carbonyl stress as well as the inflammatory cytokine release in the human periodontal ligament fibroblasts. It also leads to increased levels of cycloxygenase-2 and prostaglandin-E2 which are analogous with the up regulation of the receptor for advanced glycation end products (RAGE) by the e-cig exposure-mediated carbonyl stress in the gingival epithelium/tissue. Furthermore, the e-cigs cause an increased oxidative/carbonyl as well as inflammatory responses and the DNA damage. The present data highlights the pathologic role of the e-cig aerosol and its flavoring to the cells and tissues of oral cavity.