Sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus

In the present study, a rat model of type 2 diabetes mellitus was established by continuous peritoneal injection of streptozotocin. Following intragastric perfusion of sericin for 35 days, blood glucose levels significantly reduced, neuronal apoptosis in the hippocampal CA1 region decreased, hippoca...

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Published inNeural regeneration research Vol. 7; no. 2; pp. 197 - 201
Main Authors Chen, Zhihong, He, Yaqiang, Song, Chengjun, Dong, Zhijun, Su, Zhejun, Xue, Jingfeng
Format Journal Article
LanguageEnglish
Published Mumbai Medknow Publications & Media Pvt. Ltd 01.01.2012
Subjects
Animal cognition
Apoptosis
Biosynthesis
Biotechnology
Cell cycle
Cognitive ability
Diabetes
Glucose
Hyperglycemia
Kinases
Laboratory animals
Metabolism
Neurons
Polyclonal antibodies
Proteins
Rodents
Signal transduction
Beijing China
United States > US
China
Japan
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Summary:In the present study, a rat model of type 2 diabetes mellitus was established by continuous peritoneal injection of streptozotocin. Following intragastric perfusion of sericin for 35 days, blood glucose levels significantly reduced, neuronal apoptosis in the hippocampal CA1 region decreased, hippocampal phosphorylated Akt and nuclear factor kappa B expression were enhanced, but Bcl-xL/Bcl-2 associated death promoter expression decreased. Results demonstrated that sericin can reduce hippocampal neuronal apoptosis in a rat model of diabetes mellitus by regulating abnormal changes in the Akt signal transduction pathway.
ISSN:1673-5374
1876-7958