STUDY OF WOUND-DRESSING MATERIALS BASED ON COLLAGEN, SODIUM CARBOXYMETHYLCELLULOSE AND SILVER NANOPARTICLES USED FOR THEIR ANTIBACTERIAL ACTIVITY IN BURN INJURIESS

There are 2 types of bacteria that can produce serious infections and in many cases they lead to intestinal infections, meningitis or even toxic shock syndrome: Escherichia coli (E.coli) and Staphyloccocus aureus (S.aureus) . They are the most common source of infection worldwide and it's reall...

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Published inInternational Conference on Advanced Materials and Systems (ICAMS) pp. 123 - 128
Main Authors Leau, Sorina-Alexandra, Marin, Ştefania, Coară, Gheorghe, Albu, Luminiţa, Constantinescu, Rodica Roxana, Kaya, Mădălina Albu, Neacşu, Ionela-Andreea
Format Conference Proceeding
LanguageEnglish
Published Bucharest The National Research & Development Institute for Textiles and Leather - INCDTP 01.01.2018
Subjects
Antimicrobial agents
Bacteria
Bacterial infections
Biocompatibility
Burns
Collagen
Composite materials
E coli
Gold
Gram-negative bacteria
Gram-positive bacteria
Infections
Meningitis
Nanoparticles
Scanning electron microscopy
Sodium
Spectrum analysis
Tissue engineering
Germany
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Summary:There are 2 types of bacteria that can produce serious infections and in many cases they lead to intestinal infections, meningitis or even toxic shock syndrome: Escherichia coli (E.coli) and Staphyloccocus aureus (S.aureus) . They are the most common source of infection worldwide and it's really necessary to understand their mecanism of action. The objective of this study was to develop and characterize wound-dressing materials based on collagen (COLL), sodium carboxymethylcellulose (CMC-Na) and silver nanoparticles (AgNPs) designed to be used for burn injuries. We chose to use a composite material because it has multiple desirable effects, both on the wound and against the bacteria. Type I fibrillar collagen gel was extracted from calf hide. Sodium carboxymethylcellulose was used because it's biocompatible and non-toxic. Silver nanoparticles were used for their antimicrobial activity. Obtained wound-dressing material was characterized by FT-IR spectroscopy, scanning electronic microscopy, water up-take and degradation in collagenase solution. The results showed that this combination of materials is ideal for a faster healing of the wound and it considerably reduces the risk of infection.
ISSN:2068-0783
DOI:10.24264/icams-2018.I.18