Molecular docking analysis of timepidium with Acetylcholine and lumacaftor with GABA(A) activator

Epilepsy is a chronic disorder characterized by disturbed tissue related molecular activity within the brain irrespective of age. The cause is very difficult to understand towards a suitable treatment. However, its symptoms like seizures are treated and suppressed by known medications. Moreover, the...

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Bibliographic Details
Published inBioinformation Vol. 15; no. 11; p. 832
Main Authors Ali, Warda, Shar, Nisar A
Format Journal Article
LanguageEnglish
Published Puducherry Biomedical Informatics 01.11.2019
Subjects
Acetylcholine
Butyric acid
Epilepsy
Molecular docking
Neurotransmitters
Optimization
Seizures
γ-Aminobutyric acid
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Summary:Epilepsy is a chronic disorder characterized by disturbed tissue related molecular activity within the brain irrespective of age. The cause is very difficult to understand towards a suitable treatment. However, its symptoms like seizures are treated and suppressed by known medications. Moreover, the condition is linked with neuro-transmitters such as GABA (gamma amino butyric acid) and acetylcholine. Therefore, it is of interest to design and develop inhibitors for these targets. Hence, we describe the molecular binding features of timepidium with acetylcholine and lumacaftor with GABA(A) activator using molecular docking based geometric optimization and screening analysis for further consideration.
ISSN:0973-8894
0973-2063
DOI:10.6026/97320630015824