Challenged Immune System Improves Cognitive-Behavioral Responses In Homeostasis And Recovers Malaria-Induced Cognitive Impairment In Mice

The immune and nervous systems can be categorized as cognitive plastic systems for their ability to know and recognize real world objects, including microbes, and because of their prerogative of constant self-reorganization as they live learning experiences. After each antigenic or sensory occurrenc...

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Bibliographic Details
Published inbioRxiv
Main Authors Luciana P De Sousa Vieira, Ribeiro-Gomes, Flavia L, Almeida, Roberto F, Tadeu Mello E Souza, Werneck, Guilherme, Souza, Diogo O, Claudio Tadeu Daniel-Ribeiro
Format Paper
LanguageEnglish
Published Cold Spring Harbor Cold Spring Harbor Laboratory Press 13.12.2019
Subjects
Cognition
Cognitive ability
Homeostasis
Immune response
Immunomodulation
Inflammation
Malaria
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Summary:The immune and nervous systems can be categorized as cognitive plastic systems for their ability to know and recognize real world objects, including microbes, and because of their prerogative of constant self-reorganization as they live learning experiences. After each antigenic or sensory occurrence, vertebrate organisms experience changes in the cellular connections of their immune and nervous systems altering their abilities and structures. Elements of the immune machinery are necessary for neurocognitive function, and the pattern of the immune response triggered by different stimuli may induce regulator or deregulator signals for the nervous functions. Here we show, for the first time, that the immune modulation with anti-inflammatory stimuli can positively regulate the behavior of healthy mice and mitigate the cognitive-behavioral deficits induced by a mild infection of C57BL/6 animals with Plasmodium berghei ANKA.
DOI:10.1101/2019.12.13.874420