Sex differences in the inhibition of [gamma]-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects

• Published in: The American journal of clinical nutrition Vol. 87; no. 6; p. 1723
• Main Authors: Frank, Jan, Lee, Sangeun, Leonard, Scott W, Atkinson, Jeffrey K, Kamal-Eldin, Afaf, Traber, Maret G
• Format: Journal Article
• Language: English
• Published: Bethesda American Society for Clinical Nutrition, Inc 01.06.2008
• Subjects: Diet; Health; Metabolism; Oils & fats; Vitamin E
• ISSN: 0002-9165; 1938-3207

...-Tocopherol has unique properties that may be beneficial in sustaining optimal human health, but hepatic vitamin E metabolism enhances ...-tocopherol turnover. Our aim was to determine the extent to which dietary sesame lignans alter human - and -tocopherol metabolism and elimination as carboxyethyl hydroxychromanols (CEHCs). Healthy participants (n = 5 women and 5 men) in a randomized, crossover study (with 4-wk washout) consumed muffins prepared with either corn oil or unrefined sesame oil (sesamin, 94 mg; sesamolin, 42 mg), along with a capsule containing a 1:1 molar ratio of deuterium-labeled d...-α- and d...-...-tocopherol acetates (...50 mg each). Plasma and urine were collected up to 72 h; unlabeled and labeled tocopherol and CEHC concentrations were determined by liquid chromatography-mass spectrometry. Sesame oil muffin consumption in men, but not in women, decreased (P < 0.05) areas under plasma d...-...-CEHC concentration-time curves (area under the curve) and maximum concentrations. However, in both sexes urinary d...-...-CEHCs were decreased for 24 h following sesame oil muffin consumption. In humans, ...-tocopherol metabolism can be inhibited by the simultaneous consumption of ...-tocopherol and sesame lignans. The observed differences between men and women with respect to vitamin E metabolism warrant further investigation. (ProQuest: ... denotes formulae/symbols omitted.)