Effect of Medroxyprogesterone Acetate plus Estradiol on endothelium-depenent vasodilation in postmenopausal women

The addition of medroxyprogesterone acetate (MPA) is widely accepted to remove the endometrial-cancerogenic effect of estrogen replacement therapy in postmenopausal women. To evaluate the effect of MPA on endothelial function, we measured flow-mediated vasodilation of brachial arteries after transie...

Full description

Saved in:
Bibliographic Details
Published inThe American journal of cardiology Vol. 87; no. 2; p. 238
Main Authors Kawano, Hiroaki, Motoyama, Takeshi, Hirai, Nobutaka, Yoshimura, Toshihiro
Format Journal Article
LanguageEnglish
Published New York Elsevier Limited 15.01.2001
Subjects
Blood vessels
Cardiology
Clinical trials
Drug therapy
Hormones
Menopause
Women
Online AccessGet full text

Cover

More Information
Summary:The addition of medroxyprogesterone acetate (MPA) is widely accepted to remove the endometrial-cancerogenic effect of estrogen replacement therapy in postmenopausal women. To evaluate the effect of MPA on endothelial function, we measured flow-mediated vasodilation of brachial arteries after transient occlusion in a randomized, double-blind, placebo-controlled study; we concluded that the addition of MPA attenuates the favorable effects of estradiol on endothelium-dependent vasodilation.
ISSN:0002-9149
1879-1913