Role of nitric oxide in the regulation of HIF-1alpha expression during hypoxia
The oxygen-regulated subunit, hypoxia-inducible factor-1alpha (HIF-1alpha), is stabilized in cells exposed to hypoxia. The regulation of hypoxic responses by nitric oxide (NO) is believed to have wide pathophysiological relevance, thus Agani et al investigated whether NO affects HIF-1 activation in...
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Published in | American Journal of Physiology: Cell Physiology Vol. 52; no. 1; p. C178 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Bethesda
American Physiological Society
01.07.2002
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Subjects | |
Online Access | Get full text |
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Summary: | The oxygen-regulated subunit, hypoxia-inducible factor-1alpha (HIF-1alpha), is stabilized in cells exposed to hypoxia. The regulation of hypoxic responses by nitric oxide (NO) is believed to have wide pathophysiological relevance, thus Agani et al investigated whether NO affects HIF-1 activation in hypoxic cells. |
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ISSN: | 0363-6143 1522-1563 |