Role of nitric oxide in the regulation of HIF-1alpha expression during hypoxia

The oxygen-regulated subunit, hypoxia-inducible factor-1alpha (HIF-1alpha), is stabilized in cells exposed to hypoxia. The regulation of hypoxic responses by nitric oxide (NO) is believed to have wide pathophysiological relevance, thus Agani et al investigated whether NO affects HIF-1 activation in...

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Bibliographic Details
Published inAmerican Journal of Physiology: Cell Physiology Vol. 52; no. 1; p. C178
Main Authors Agani, Faton H, Puchowicz, Michelle, Chavez, Juan Carlos, Pichiule, Paola, LaManna, Joseph
Format Journal Article
LanguageEnglish
Published Bethesda American Physiological Society 01.07.2002
Subjects
Cells
Nitric oxide
Oxygen
Proteins
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Summary:The oxygen-regulated subunit, hypoxia-inducible factor-1alpha (HIF-1alpha), is stabilized in cells exposed to hypoxia. The regulation of hypoxic responses by nitric oxide (NO) is believed to have wide pathophysiological relevance, thus Agani et al investigated whether NO affects HIF-1 activation in hypoxic cells.
ISSN:0363-6143
1522-1563