Caffeine modulates Ca2positive receptor activation in isolated rat osteoclasts and induces intracellular Ca2positive release

The theory that Ni2positive-induced elevations of cytosolic (Ca2positive) in the rat osteoclast might involve a ryanodine receptor-mediated pathway was tested. Caffeine triggers intracellular Ca2positive release and inhibits Ca2positive-receptor activation in the isolated rat osteoclast.

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Bibliographic Details
Published inAmerican journal of physiology. Renal physiology Vol. 37; no. 3; p. F447
Main Authors Shankar, Vijai S, Pazianas, Michael, Huang, Christopher L-H, Simon, Bruce
Format Journal Article
LanguageEnglish
Published Bethesda American Physiological Society 01.03.1995
Subjects
Biochemistry
Caffeine
Cellular biology
Kidneys
Rodents
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Summary:The theory that Ni2positive-induced elevations of cytosolic (Ca2positive) in the rat osteoclast might involve a ryanodine receptor-mediated pathway was tested. Caffeine triggers intracellular Ca2positive release and inhibits Ca2positive-receptor activation in the isolated rat osteoclast.
ISSN:1931-857X
1522-1466