Effect of alpha-KG in lumen on PAH transport by isolated perfused rabbit renal proximal tubules

Alpha-ketoglutarate (alpha-KG) that enters the rabbit renal proximal tubule cells via the luminal sodium-dicarboxylate cotransporter can stimulate net p-aminohippurate secretion, but only when tubules are not in an optimal metabolic state to produce intracellular alpha-KG.

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Bibliographic Details
Published inAmerican journal of physiology. Renal physiology Vol. 40; no. 3; p. F521
Main Authors Dantzler, William H, Evans, Kristen K
Format Journal Article
LanguageEnglish
Published Bethesda American Physiological Society 01.09.1996
Subjects
Biochemistry
Cells
Kidneys
Metabolism
Rabbits
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Summary:Alpha-ketoglutarate (alpha-KG) that enters the rabbit renal proximal tubule cells via the luminal sodium-dicarboxylate cotransporter can stimulate net p-aminohippurate secretion, but only when tubules are not in an optimal metabolic state to produce intracellular alpha-KG.
ISSN:1931-857X
1522-1466