Effect of alpha-KG in lumen on PAH transport by isolated perfused rabbit renal proximal tubules
Alpha-ketoglutarate (alpha-KG) that enters the rabbit renal proximal tubule cells via the luminal sodium-dicarboxylate cotransporter can stimulate net p-aminohippurate secretion, but only when tubules are not in an optimal metabolic state to produce intracellular alpha-KG.
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Published in | American journal of physiology. Renal physiology Vol. 40; no. 3; p. F521 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Bethesda
American Physiological Society
01.09.1996
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Subjects | |
Online Access | Get full text |
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Summary: | Alpha-ketoglutarate (alpha-KG) that enters the rabbit renal proximal tubule cells via the luminal sodium-dicarboxylate cotransporter can stimulate net p-aminohippurate secretion, but only when tubules are not in an optimal metabolic state to produce intracellular alpha-KG. |
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ISSN: | 1931-857X 1522-1466 |