Mutations in BHD and TP53 genes, but not in HNF1[beta] gene, in a large series of sporadic chromophobe renal cell carcinoma

BHD, TP53, and HNF1beta on chromosome 17 were studied in 92 cases of renal cell carcinoma (46 chromophobe, 19 clear cell, 18 oncocytoma, and nine papillary). Six, thirteen, and zero cases had, respectively BHD, TP53, and HNF1beta mutations, (84% mutations involved chromophobe), suggesting a role for...

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Bibliographic Details
Published inBritish journal of cancer Vol. 96; no. 2; p. 336
Main Authors Gad, S, Lefèvre, S H, Khoo, S K, Giraud, S, Vieillefond, A, Vasiliu, V, Ferlicot, S, Molinié, V, Denoux, Y, Thiounn, N, Chrétien, Y, Méjean, A, Zerbib, M, Benoît, G, Hervé, J M, Allègre, G, B Bressac-de Paillerets, Teh, B T, Richard, S
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group 29.01.2007
Subjects
Cancer research
Chromosomes
DNA methylation
Genes
Genomics
Kidney cancer
Medical research
Mutation
Patients
Polymorphism
Tumors
United States > US
Paris France
France
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Summary:BHD, TP53, and HNF1beta on chromosome 17 were studied in 92 cases of renal cell carcinoma (46 chromophobe, 19 clear cell, 18 oncocytoma, and nine papillary). Six, thirteen, and zero cases had, respectively BHD, TP53, and HNF1beta mutations, (84% mutations involved chromophobe), suggesting a role for BHD and TP53 in chromophobe subtype.
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6603492