Vagotomy attenuates but not does not prevent the somnogenic and febrile effects of lipopolysaccharide in rats

The role of the vagus nerve in the somnogenic and pyrogenic effects of lipopolysaccharide (LPS) was studied in rats. Control rats (n = 8) and rats subjected to bilateral subdiaphragmal vagotomy (VX; n = 9) were injected with 100 micrograms/kg ip LPS at the beginning of the dark period.

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Bibliographic Details
Published inAmerican journal of physiology. Regulatory, integrative and comparative physiology Vol. 43; no. 2; p. R406
Main Authors Kapas, Levente, Hansen, Michael K, Chang, Hee-Yoon, Krueger, James M
Format Journal Article
LanguageEnglish
Published Bethesda American Physiological Society 01.02.1998
Subjects
Brain
Cytokines
Nervous system
Rodents
Sleep
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Summary:The role of the vagus nerve in the somnogenic and pyrogenic effects of lipopolysaccharide (LPS) was studied in rats. Control rats (n = 8) and rats subjected to bilateral subdiaphragmal vagotomy (VX; n = 9) were injected with 100 micrograms/kg ip LPS at the beginning of the dark period.
ISSN:0363-6119
1522-1490