Enhanced PKC(beta)II translocation and PKC(Beta)II-RACK1 interactions in PKC(epsilon)-induced heart failure: A role for RACK1

Recent investigations have established a role for the betaII-isoform of protein kinase C (PKCbetaII) in the induction of cardiac hypertrophy and failure. Although receptors for activated C kinase (RACKs) have been shown to direct PKC signal transduction, the mechanism through which RACK1, a selectiv...

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Bibliographic Details
Published inAmerican journal of physiology. Heart and circulatory physiology Vol. 50; no. 6; p. H2500
Main Authors Pass, Jason M, Gao, Jiuming, Jones, W Keith, Wead, William B
Format Journal Article
LanguageEnglish
Published Bethesda American Physiological Society 01.12.2001
Subjects
Cardiology
Cardiovascular disease
Enzymes
Proteins
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Summary:Recent investigations have established a role for the betaII-isoform of protein kinase C (PKCbetaII) in the induction of cardiac hypertrophy and failure. Although receptors for activated C kinase (RACKs) have been shown to direct PKC signal transduction, the mechanism through which RACK1, a selective PKCbetaII RACK, participates in PKCbetaII-mediated cardiac hypertrophy and failure remains undefined.
ISSN:0363-6135
1522-1539