The Global Virulence Regulator PhcA Negatively Controls the Ralstonia solanacearum hrp Regulatory Cascade by Repressing Expression of the PrhlR Signaling Proteins

PhcA positively and negatively regulates many genes responsible for pathogenicity of Ralstonia solanacearum. The type III secretion system-encoding hrp regulon is one of the negatively controlled operons. PhcA bound to the promoter region of prhIR and repressed its expression, demonstrating that Phc...

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Bibliographic Details
Published inJournal of bacteriology Vol. 191; no. 10; p. 3424
Main Authors Yoshimochi, Takeshi, Hikichi, Yasufumi, Kiba, Akinori, Ohnishi, Kouhei
Format Journal Article
LanguageEnglish
Published Washington American Society for Microbiology 01.05.2009
Subjects
Bacteria
Bacteriology
Gene expression
Proteins
Signal transduction
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Summary:PhcA positively and negatively regulates many genes responsible for pathogenicity of Ralstonia solanacearum. The type III secretion system-encoding hrp regulon is one of the negatively controlled operons. PhcA bound to the promoter region of prhIR and repressed its expression, demonstrating that PhcA shuts down the most upstream component of a signal transfer system for hrpB activation. [PUBLICATION ABSTRACT]
ISSN:0021-9193
1098-5530