The yeast model for batten disease: Mutations in btn1, btn2, and hsp30 alter pH homeostatis

• Published in: Journal of bacteriology Vol. 182; no. 22; p. 6418
• Main Authors: Chattopadhyay, Subrata, Muzaffar, Neda E, Sherman, Fred, Pearce, David A
• Format: Journal Article
• Language: English
• Published: Washington American Society for Microbiology 01.11.2000
• Subjects: Bacteriology; Disease; Genes; Mutation; Proteins; Yeast

The BTN1 gene product of the yeast Saccharomyces cerevisiae is 30% identical and 59% similar to human CLN3, which is associated with the neurodegenerative disorder Batten disease. The function of the CLN3 protein and the molecular basis for the disease remain elusive.