The yeast model for batten disease: Mutations in btn1, btn2, and hsp30 alter pH homeostatis

The BTN1 gene product of the yeast Saccharomyces cerevisiae is 30% identical and 59% similar to human CLN3, which is associated with the neurodegenerative disorder Batten disease. The function of the CLN3 protein and the molecular basis for the disease remain elusive.

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Bibliographic Details
Published inJournal of bacteriology Vol. 182; no. 22; p. 6418
Main Authors Chattopadhyay, Subrata, Muzaffar, Neda E, Sherman, Fred, Pearce, David A
Format Journal Article
LanguageEnglish
Published Washington American Society for Microbiology 01.11.2000
Subjects
Bacteriology
Disease
Genes
Mutation
Proteins
Yeast
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Summary:The BTN1 gene product of the yeast Saccharomyces cerevisiae is 30% identical and 59% similar to human CLN3, which is associated with the neurodegenerative disorder Batten disease. The function of the CLN3 protein and the molecular basis for the disease remain elusive.
ISSN:0021-9193
1098-5530