[beta]-Sheet modeling by helical surfaces

We present a topological description of a [beta]-sheet in terms of a piece of helical surface. It requires only two easy-to-handle parameters: the twist, i.e. the turn of the helical surface per residue, and the coiling, which is a curvature along the strands or in the direction perpendicular to the...

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Bibliographic Details
Published inProtein engineering, design and selection Vol. 13; no. 6; p. 407
Main Authors Znamenskiy, Denis, Khan Le Tuan, Poupon, Anne, Chomilier, Jacques, Jean-Paul Mornon
Format Journal Article
LanguageEnglish
Published Oxford Oxford Publishing Limited (England) 01.06.2000
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Summary:We present a topological description of a [beta]-sheet in terms of a piece of helical surface. It requires only two easy-to-handle parameters: the twist, i.e. the turn of the helical surface per residue, and the coiling, which is a curvature along the strands or in the direction perpendicular to the strands of the sheet. This method applies fairly well to three- and four-strand sheets, forming a too limited structure to be able to build a barrel. From an analysis of [beta]-sheets derived from a structural database, we show that this picture can even be reduced to the use of one main value, the twist angle. The dependence of [beta]-sheet twisting on the number of strands in a sheet, and also on the length and direction of strands, has been demonstrated. The applications of such a description may include the rapid modeling of 3D structures.
ISSN:1741-0126
1741-0134