Adult acute megakaryoblastic leukemia: rare association with cytopenias of undetermined significance and p210 and p190BCR–ABL transcripts

Acute megakaryocytic leukemia (M7-AML) is a rare form of acute myeloid leukemia (AML), which is associated with poor prognosis. The case presented in the current report is a statement for the difficult diagnosis and clinical management of M7-AML in the context of a previous hematologic disorder of u...

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Published inOncoTargets and therapy Vol. 10; p. 5047
Main Authors Dima, Delia, Oprita, Liana, Rosu, Ana-Maria, Trifa, Adrian, Selicean, Cristina, Moisoiu, Vlad, Frinc, Ioana, Zdrenghea, Mihnea, Tomuleasa, Ciprian
Format Journal Article
LanguageEnglish
Published Macclesfield Taylor & Francis Ltd 01.01.2017
Subjects
Antigens
Bone marrow
Chemotherapy
Clinical outcomes
Enzyme inhibitors
Family medical history
Hematological diseases
Hematology
Leukemia
Lymphatic system
Lymphoma
Medical prognosis
Patients
Stem cells
Working groups
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Summary:Acute megakaryocytic leukemia (M7-AML) is a rare form of acute myeloid leukemia (AML), which is associated with poor prognosis. The case presented in the current report is a statement for the difficult diagnosis and clinical management of M7-AML in the context of a previous hematologic disorder of undetermined significance and associated genetic abnormalities. Probably, following the complete hematologic remission and further with induction chemotherapy plus tyrosine kinase inhibitor therapy, the clinical management of this case will be followed by a allogeneic bone marrow transplantation, the only proven therapy to improve overall survival.
ISSN:1178-6930
DOI:10.2147/OTT.S146973