Histone macroH2A 1.2 is concentrated in the XY compartment of mammalian male meiotic nuclei

We show here that histone macroH2A1.2 concentrates at the transcriptionally silent XY body, normally being formed during male meiosis in the mouse. A similar accumulation has earlier been observed on the inactive X chromosomes of somatic adult female mammalian cells by Costanzi and Pehrson (1998). T...

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Bibliographic Details
Published inCytogenetic and genome research Vol. 89; no. 1/2; p. 118
Main Authors Richler, C, Dhara, S K, Wahrman, J
Format Journal Article
LanguageEnglish
Published Basel S. Karger AG 01.01.2000
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Summary:We show here that histone macroH2A1.2 concentrates at the transcriptionally silent XY body, normally being formed during male meiosis in the mouse. A similar accumulation has earlier been observed on the inactive X chromosomes of somatic adult female mammalian cells by Costanzi and Pehrson (1998). This correspondence in the nature of heterochromatinization of the X chromosomes in males and females adds another property of X chromosome inactivation that is shared by males and females at different phases of their life cycle. Copyright 2000 S. Karger AG, Basel.
ISSN:1424-8581
1424-859X