Tadalafil

Erectile dysfunction (ED) affects a great number of patients. Type 5 phosphodiesterase inhibitors (PDE-5) are, at the present time, the drugs most widely utilized in the treatment of ED. Tadalafil is a highly selective and reversible inhibitor of PDE-5. After its oral administration, it is absorbed...

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Bibliographic Details
Published inPA AP no. 37; p. 34
Main Authors J. Honorato Pérez, I. Gil Aldea, A.E. Catena Sánchez
Format Journal Article
LanguageEnglish
Published Barcelona Ediciones Mayo 01.10.2004
Subjects
Prescription drugs
Sexual disorders
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Summary:Erectile dysfunction (ED) affects a great number of patients. Type 5 phosphodiesterase inhibitors (PDE-5) are, at the present time, the drugs most widely utilized in the treatment of ED. Tadalafil is a highly selective and reversible inhibitor of PDE-5. After its oral administration, it is absorbed rapidly, is metabolized by CYP3A4 and has a clearance half-life of 17.5 hours. The effect of tadalafil takes placce between 20 and 30 minutes after administration and lasts for 24 hours. Some studies have demonstrated that the effect can still persist 36 hours after administration. Clinical trials show an efficacy of approximately 85%. In preference tests, tadalafil has produced better results than other drugs of its class. In terms of safety, interactions of tadalafil with other substances are uncommon. Its use in combination with nitrates is contraindicated.
ISSN:1139-1596