CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL: Case 27-2004

On microscopical examination, there were glassy, flame-shaped eosinophilic inclusions in the cytoplasm of oligodendrocytes in the white matter of the cerebellum, the pons, and the cerebral hemispheres; the inclusions were positive for [alpha]-synuclein on immunostaining (Fig. 3A). These oligodendrog...

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Published inThe New England journal of medicine Vol. 351; no. 9; p. 912
Main Authors Schlossmacher, Michael G, Hamann, Claus, Cole, Alan G, Gonzalez, R Gilberto, Frosch, Matthew P
Format Journal Article
LanguageEnglish
Published Boston Massachusetts Medical Society 26.08.2004
Subjects
Brain
Disease management
Medical diagnosis
Neurological disorders
Neurology
Patients
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Summary:On microscopical examination, there were glassy, flame-shaped eosinophilic inclusions in the cytoplasm of oligodendrocytes in the white matter of the cerebellum, the pons, and the cerebral hemispheres; the inclusions were positive for [alpha]-synuclein on immunostaining (Fig. 3A). These oligodendroglial inclusions were originally characterized by means of silver-impregnation methods and by immunostaining for ubiquitin, and they are the histopathological hallmark of multiple-system atrophy (Fig. 3B).
ISSN:0028-4793
1533-4406