Respiratory syncytial virus affects pulmononary function in BALB/c mice

BALB/c mice inoculated intranasally with respiratory syncytial virus (RSV) were studied in a whole-body plethysmograph to determine if signs of respiratory illness similar to those observed in human infants could be detected. Also, responsiveness to methacholine was assessed. RSV-infected mice showe...

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Bibliographic Details
Published inThe Journal of infectious diseases Vol. 177; no. 2; p. 269
Main Authors van Schaik, Sandrijn M, Enhorning, Goran, Vargas, Ida, Welliver, Robert C
Format Journal Article
LanguageEnglish
Published Oxford Oxford University Press 01.02.1998
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Summary:BALB/c mice inoculated intranasally with respiratory syncytial virus (RSV) were studied in a whole-body plethysmograph to determine if signs of respiratory illness similar to those observed in human infants could be detected. Also, responsiveness to methacholine was assessed. RSV-infected mice showed significantly higher respiratory rates than did controls (409.2 vs. 305.2 breaths/min, P < .0001). Significantly increased airway responsiveness to methacholine was noted, infected mice responding to a 100-fold lower dose than controls (P = .003). Together, these data provide the first objective evidence of respiratory illness in the mouse model of RSV infection, which enhances the value of this model for evaluating effects of vaccines, antivirals, and other drugs acting on respiratory tract disease caused by RSV.
ISSN:0022-1899
1537-6613