Cross-clade cytotoxin T cell response to human immunodeficiency virus type 1 proteins among HLA disparate North Americans and Thais

A globally effective vaccine will need to elicit cytotoxic T lymphocytes (CTL) capable of recognizing diverse human immunodeficiency virus type 1 (HIV-1) clades. Study of the cellular immune responses of HIV-1-infected persons may allow predictions to be made regarding useful vaccine antigen compone...

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Bibliographic Details
Published inThe Journal of infectious diseases Vol. 178; no. 4; p. 1040
Main Authors Lynch, Julia A, deSouza, Mark, Robb, Merlin D, Markowitz, Lauri
Format Journal Article
LanguageEnglish
Published Oxford Oxford University Press 01.10.1998
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Summary:A globally effective vaccine will need to elicit cytotoxic T lymphocytes (CTL) capable of recognizing diverse human immunodeficiency virus type 1 (HIV-1) clades. Study of the cellular immune responses of HIV-1-infected persons may allow predictions to be made regarding useful vaccine antigen components. The frequency and magnitude of CTL responses to clade E and B Gag, Pol-RT, Env, and Nef proteins were compared in 12 HLA-characterized, clade E-infected Thais and in 10 clade B-infected North Americans using vaccinia recombinant constructs for protein expression. While responses were detected against all proteins, they were most frequent and cross-reactive to Gag in both groups. Pol-RT was recognized less frequently in Thais than North Americans. Cross-clade protein recognition was common but not uniformly present among these HLA-disparate individuals. Population-specific CTL data are needed to adequately prepare for vaccine trials outside of North America and Europe.
ISSN:0022-1899
1537-6613