Immunoepidemiologic Profile of Chlamydia trachomatis Infection: Importance of Heat-Shock Protein 60 and Interferon-[gamma]
Epidemiological, animal, and in vitro investigations suggest that Chlamydia trachomatis infection engenders acquired immunity, the basis for which is incompletely defined, especially in humans. In a prospective cohort study of women at high risk for C. trachomatis infection, we found that, at baseli...
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| Published in | The Journal of infectious diseases Vol. 192; no. 4; p. 591 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford
Oxford University Press
15.08.2005
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| Online Access | Get full text |
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| Abstract | Epidemiological, animal, and in vitro investigations suggest that Chlamydia trachomatis infection engenders acquired immunity, the basis for which is incompletely defined, especially in humans. In a prospective cohort study of women at high risk for C. trachomatis infection, we found that, at baseline and after adjustment for age and other potential confounding variables, production of interferon- gamma by peripheral-blood mononuclear cells (PBMCs) stimulated with chlamydia heat-shock protein 60 strongly correlated with protection against incident C. trachomatis infection. This investigation supports a direct role for C. trachomatis-specific immune responses in altering the risk of infection and suggests immune correlates of protection that are potentially useful in vaccine development. |
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| AbstractList | Epidemiological, animal, and in vitro investigations suggest that Chlamydia trachomatis infection engenders acquired immunity, the basis for which is incompletely defined, especially in humans. In a prospective cohort study of women at high risk for C. trachomatis infection, we found that, at baseline and after adjustment for age and other potential confounding variables, production of interferon- gamma by peripheral-blood mononuclear cells (PBMCs) stimulated with chlamydia heat-shock protein 60 strongly correlated with protection against incident C. trachomatis infection. This investigation supports a direct role for C. trachomatis-specific immune responses in altering the risk of infection and suggests immune correlates of protection that are potentially useful in vaccine development. |
| Author | Meier, Amalia S Cohen, Craig R Koochesfahani, Kasra M Shen, Caixia |
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| Copyright | Copyright University of Chicago Press Aug 15, 2005 |
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| Title | Immunoepidemiologic Profile of Chlamydia trachomatis Infection: Importance of Heat-Shock Protein 60 and Interferon-[gamma] |
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