Immunoepidemiologic Profile of Chlamydia trachomatis Infection: Importance of Heat-Shock Protein 60 and Interferon-[gamma]

Epidemiological, animal, and in vitro investigations suggest that Chlamydia trachomatis infection engenders acquired immunity, the basis for which is incompletely defined, especially in humans. In a prospective cohort study of women at high risk for C. trachomatis infection, we found that, at baseli...

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Published inThe Journal of infectious diseases Vol. 192; no. 4; p. 591
Main Authors Cohen, Craig R, Koochesfahani, Kasra M, Meier, Amalia S, Shen, Caixia
Format Journal Article
LanguageEnglish
Published Oxford Oxford University Press 15.08.2005
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Summary:Epidemiological, animal, and in vitro investigations suggest that Chlamydia trachomatis infection engenders acquired immunity, the basis for which is incompletely defined, especially in humans. In a prospective cohort study of women at high risk for C. trachomatis infection, we found that, at baseline and after adjustment for age and other potential confounding variables, production of interferon- gamma by peripheral-blood mononuclear cells (PBMCs) stimulated with chlamydia heat-shock protein 60 strongly correlated with protection against incident C. trachomatis infection. This investigation supports a direct role for C. trachomatis-specific immune responses in altering the risk of infection and suggests immune correlates of protection that are potentially useful in vaccine development.
ISSN:0022-1899
1537-6613