Allergic asthma is inversely associated with Helicobacter pylori seropositivity

H. pylori is a gram negative bacterium, it is considered a well-known risk factor for developing peptic ulcer, gastric cancer and gastric lymphoma (12-14). Of these, H. pylori neutrophil-activating protein (HP-NAP) has been found to induce the release of IL-12 and IFN-y when administered systemicall...

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Published inJournal of pharmaceutical sciences and research Vol. 11; no. 5; pp. 2039 - 2041
Main Authors Odhar, Hasanain Abdulhameed, Hasan, Mohammed Abbas, Rayshan, Ali Mahmood, Hasan, Murtada Falah, Mahmmod, Suqayna Habeeb, Majid, Huda Kahtan
Format Journal Article
LanguageEnglish
Published Cuddalore Journal of Pharmaceutical Sciences and Research 01.05.2019
Subjects
Allergies
Arthritis
Asthma
Cancer
Cytokines
Gastroenterology
Gastroesophageal reflux
Hypotheses
Immune system
Immunoglobulins
Immunology
Infections
Infectious diseases
Inflammation
Lymphocytes
Lymphoma
Neutrophils
Pathogens
Physiology
Studies
Teaching hospitals
Volunteers
England
Iraq
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Summary:H. pylori is a gram negative bacterium, it is considered a well-known risk factor for developing peptic ulcer, gastric cancer and gastric lymphoma (12-14). Of these, H. pylori neutrophil-activating protein (HP-NAP) has been found to induce the release of IL-12 and IFN-y when administered systemically (16-18). [...]HPNAP can be utilized for the development of a potential preventive approach against allergic asthma (9, 19). According to regression analysis, the prevalence of H. pylori IgG antibodies was more common among control patients (67%) as compared to asthmatic ones (37%); (P value = 0.009; Odds ratio = 5.50; confidence interval = 1.54-19.63). [...]analysis of other samples may be required to elaborate the current potential relationship between Helicobacter pylori infection and allergic asthma prevalence as some previous studies failed to report any significant link between these two variables (27).
ISSN:0975-1459