The BIGTT Test: A novel test for simultaneous measurement of pancreatic [beta]-cell function, insulin sensitivity, and glucose tolerance
Insulin resistance and impaired β-cell function are key elements in the pathogenesis of type 2 diabetes. We aimed to develop valid algorithms for estimation of the insulin sensitivity index (S^sub I^) and acute insulin response (AIR) derived from simple and cheap physiological measurements that coul...
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Published in | Diabetes care Vol. 30; no. 2; p. 257 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Alexandria
American Diabetes Association
01.02.2007
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Subjects | |
Online Access | Get full text |
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Summary: | Insulin resistance and impaired β-cell function are key elements in the pathogenesis of type 2 diabetes. We aimed to develop valid algorithms for estimation of the insulin sensitivity index (S^sub I^) and acute insulin response (AIR) derived from simple and cheap physiological measurements that could be used in large-scale metabolic, genetic, and epidemiological studies. For our purpose, data from an oral glucose tolerance test (OGTT) (18 samples during 240 min) and a tolbutamide-modified intravenous glucose tolerance test (IVGTT) (33 samples during 180 min) from 258 individuals with fasting plasma glucose <7 mmol/l and 2-h plasma glucose <7.8 mmol/l were used for model development and internal validation. Data from an additional 28 individuals were used for external validation. Bergman's minimal model was used to calculate S^sub I^, and the trapezoidal method was used to calculate AIR^sub 0-8 min^. Multiple linear regression was applied to derive predictive equations of log(S^sub I^) and log(AIR^sub 0-8 min^) using data on sex, BMI, plasma glucose, and serum insulin levels obtained during the OGTT. We demonstrate that it is possible to obtain estimates of S^sub I^ (BIGTT-S^sub I^) and AIR (BIGTT-AIR) that are highly correlated to IVGTT-derived values of S^sub I^ (R^sup 2^ = 0.77) and AIR (R^sup 2^ = 0.54). In the two validation datasets we obtained similar results. Data from OGTTs can provide accurate measures of insulin sensitivity and β-cell function, which can be used in large scale metabolic, genetic, and epidemiological studies. |
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ISSN: | 0149-5992 |
DOI: | 10.2337/dc06-1240 |