gp49B1-[alpha]v[beta]3 interaction inhibits antigen-induced mast cell activation

We have identified the integrin alpha(v)beta3 as a ligand for mouse gp49B1, thus identifying a new class of ligand for a member of the family of inhibitory immunoreceptors that bear C2-type immunoglobulin-like domains. The specific interaction was shown by both cell-protein and cell-cell binding ass...

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Published inNature immunology Vol. 2; no. 5; p. 436
Main Authors Castells, Mariana C, Klickstein, Lloyd B, Hassani, Kevin, Cumplido, Jose A, Lacouture, Mario E, Austen, K Frank, Katz, Howard R
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group 01.05.2001
Subjects
Bone marrow
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Summary:We have identified the integrin alpha(v)beta3 as a ligand for mouse gp49B1, thus identifying a new class of ligand for a member of the family of inhibitory immunoreceptors that bear C2-type immunoglobulin-like domains. The specific interaction was shown by both cell-protein and cell-cell binding assays. In addition, we found that the interaction of alpha(v)beta3 with gp49B1 on bone marrow-derived mouse mast cells inhibited antigen-induced immunoglobulin E-mediated cell activation. Because neither gp49B1 nor alpha(v)beta3 exhibit substantive allelic variation, their newly appreciated interaction may reflect an innate pathway for down-regulating the activity of mast cells.
ISSN:1529-2908
1529-2916
DOI:10.1038/87749