Bilirubin Damgalı Kitosan-Agaroz Biyomateryalinin Sentezi, Karakterizasyonu ve Bilirubin Uzaklaştırılmasında Kullanımı

Aim: This study was conducted to synthesize and characterize bilirubin imprinted chitosan-agarose biomaterial and to determine its significance on bilirubin removal.Method: Natural Chitosan and agarose polymers were chosen as materials. Human plasma was used to determine the capacity of bilirubin im...

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Bibliographic Details
Published inİstanbul gelişim üniversitesi sağlık bilimleri dergisi : (Online) no. 5; p. 451
Main Authors Arzu KAYA KOÇDOĞAN, ÇETİN, Sema
Format Journal Article
LanguageEnglish
Turkish
Published Istanbul Istanbul Gelisim University 01.08.2018
Subjects
Adsorption
Bile
Molecular biology
Plasma
Toxins
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Summary:Aim: This study was conducted to synthesize and characterize bilirubin imprinted chitosan-agarose biomaterial and to determine its significance on bilirubin removal.Method: Natural Chitosan and agarose polymers were chosen as materials. Human plasma was used to determine the capacity of bilirubin imprinted chitosan-agarose biomaterial for bilirubin removal.Findings: The optimum conditions for bilirubin removal were determined as pH 7.0 at 37oC with a starting concentration of 40 mg/g. An increase in NaCl concentration was shown to decrease the ionic strength for bilirubin.Conclusion: Bilirubin analysis was performed on serum samples taken before and after the interaction. A suspension rate of 87% was obtained by using molecular imprinted chitosan-agarose biomaterials. When bilirubin adsorption from aqueous solutions was compared to the adsorption of bilirubin from human plasma it was observed that the adsorption capacity of plasma was slightly decreased.
ISSN:2536-4499
2602-2605