Resveratrol with an adjunct for improved maintenance of mitochondrial homeostasis and dopamine neuronal rescue in neurodegeneration

In PD postmortem brain tissues, a-synuclein accumulation and increase in oxidative stress and disturbance in mitochondrial function was observed [7]. [...]dysfunction of antioxidant defense system due to depletion of antioxidant enzymes like glutathione peroxidase (GPX), superoxide dismutase (SOD) c...

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Published inJournal of pharmaceutical sciences and research Vol. 11; no. 4; pp. 1210 - 1215
Main Authors Nair, Arun T, Vadivelan, R, Ramachandran, Rajesh, Ahamed, Haja Nazeer
Format Journal Article
LanguageEnglish
Published Cuddalore Journal of Pharmaceutical Sciences and Research 01.04.2019
Subjects
Alzheimer's disease
Antioxidants
Brain
Cell culture
Cyclin-dependent kinases
Dopamine
Enzymes
Homeostasis
Kinases
Neuroblastoma
Neurodegeneration
Neurons
Oxidative stress
Parkinson's disease
Phosphorylation
Proteins
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Summary:In PD postmortem brain tissues, a-synuclein accumulation and increase in oxidative stress and disturbance in mitochondrial function was observed [7]. [...]dysfunction of antioxidant defense system due to depletion of antioxidant enzymes like glutathione peroxidase (GPX), superoxide dismutase (SOD) cause the fragmentation of mitochondria, which will eventually lead to the decline in respiration and mitochondrial complex 1 activity, ultimately causing neuronal death [8]. Additionally, DA neurons within the SN are particularly sensitive to oxidative damage from mitochondrial-derived reactive oxygen species (ROS) [9]. [...]mitochondrial quality control through proper balance of mitochondrial homeostasis proves to be vital for treating neurodegeneration in PD. Cyclin dependent kinase-5 (CDK5) is a protein kinase enzyme encoded by the CDK5gene. [...]regulation of CDK5 and its phosphorylation could be considered as a viable therapeutic option for PD. The pharmacological treatments of PD currently available are all of symptomatic therapy [13]. [...]developing a treatment strategy that can stop or slow the process of neurodegeneration holds a great potential in PD. Resveratrol is a polyphenolic compound with antioxidant, anti-inflammatory, anti-apoptotic and neurotrophic properties [16], which could produce neuroprotective effects against neurodegeneration by controlling the oxidative and inflammatory mechanisms in the pathogenesis of PD [17].Maintenance of mitochondrial quality through the proper balance of biogenesis and degradation within the SN, as well as other brain regions is a pivotal step in preventing neurodegeneration in both familial and age-related PD [18].
ISSN:0975-1459