Dual Function of Transforming Growth Factor-[beta] in the Control of Proliferation and Apoptosis of Cells of the Nervous System

Transforming growth factor-[beta] (TGF-[beta]) is an agent that gave the name to an extensive superfamily of congeneric cytokines playing important roles in numerous physiological and pathological processes. TGF-[beta] is involved in a few signal pathways controlling growth, differentiation, and dea...

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Bibliographic Details
Published inNeurophysiology (New York) Vol. 33; no. 5; p. 331
Main Authors Stoika, R S, Fil'chenkov, O O
Format Journal Article
LanguageEnglish
Published New York Springer Nature B.V 01.09.2001
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Summary:Transforming growth factor-[beta] (TGF-[beta]) is an agent that gave the name to an extensive superfamily of congeneric cytokines playing important roles in numerous physiological and pathological processes. TGF-[beta] is involved in a few signal pathways controlling growth, differentiation, and death (apoptosis) of the nerve cells. Yet, it was found that the role of TGF-[beta] in each of these processes is dual: it can act either as their stimulator or as an inhibitor. This review describes examples and principal mechanisms of the dual functions of TGF-[beta] in its regulatory influences realized in the mammalian nervous system.
ISSN:0090-2977
1573-9007