High-level heterologous expression and secretion in Streptomyces lividans of two major antigenic protein from Mycobacterium tuberculosis

Two major antigens from Mycobacterium tuberculosis were produced by Streptomyces lividans as secreted extracellular proteins. An expression-secretion vector had been constructed that contained the promoter of xylanase A and the signal sequence of cellulase A.

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Bibliographic Details
Published inCanadian journal of microbiology Vol. 48; no. 1; p. 43
Main Authors Tremblay, Donald, Lemay, Johanne, Gilbert, Michel, Chapdelaine, Yvan
Format Journal Article
LanguageEnglish
Published Ottawa Canadian Science Publishing NRC Research Press 01.01.2002
Subjects
Bacteria
Microbiology
Peptides
Proteins
Tuberculosis
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Summary:Two major antigens from Mycobacterium tuberculosis were produced by Streptomyces lividans as secreted extracellular proteins. An expression-secretion vector had been constructed that contained the promoter of xylanase A and the signal sequence of cellulase A.
ISSN:0008-4166
1480-3275