Kinetic resolution of oxime esters with lipases--synthesis of enantiomerically enriched building blocks with quaternary carbon centers and formal total synthesis of perhydro

Enantiomerically enriched oximes bearing stereogenic quaternary carbon centers can be obtained by lipase-catalyzed kinetic resolution of oxime esters. Substrate specificity, solvent effects and the use of different lipases are discussed in this study.

Saved in:
Bibliographic Details
Published inCanadian journal of chemistry Vol. 80; no. 6; p. 686
Main Authors Diedrichs, Nicole, Krelaus, Ralf, Gedrath, Ina, Westermann, Bernhard
Format Journal Article
LanguageEnglish
Published Ottawa Canadian Science Publishing NRC Research Press 01.06.2002
Subjects
Catalysts
Chemical reactions
Enzymes
Esters
Organic chemistry
Online AccessGet full text

Cover

More Information
Summary:Enantiomerically enriched oximes bearing stereogenic quaternary carbon centers can be obtained by lipase-catalyzed kinetic resolution of oxime esters. Substrate specificity, solvent effects and the use of different lipases are discussed in this study.
ISSN:0008-4042
1480-3291