Detection and clinical significance of NO, cytokines in serum and red-cell immune functions on patients with gastric cancer / 胃癌患者血清NO、细胞因子和红细胞免疫功能的测定及其意义

目的研究胃癌发病的免疫学机制.方法应用形态学方法测定胃癌患者RBC-C3bRR、RBC-ICR及NTER;用ELISA法测定血清TNF-α、IL-6和IL-8含量;用生化方法测定血清NO含量.结果胃癌患者血清NO含量,RBC-C3bRR和NTER明显降低(P均<0.05),术后较术前明显升高(P均<0.05),但仍低于对照组(P均<0.05).血清TNF-α、IL-6、IL-8含量及RBC-ICR明显增高(P均<0.05),术后血清IL-6、IL-8含量及RBC-ICR较术前明显降低(P均<0.05),但仍高于对照组(P均<0.05).胃癌患者TNF-α、I...

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Published inXi'an jiao tong da xue xue bao. Journal of Xi'an Jiaotong University (medical sciences). Yi xue ban no. 1; p. 73
Main Authors 佟书娟, 陈军, 王宁萍, 赵建宁, 周娅
Format Journal Article
LanguageChinese
Published Xi'an Xi'an Jiaotong University 01.01.2004
Subjects
Clinical significance
Gastric cancer
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Summary:目的研究胃癌发病的免疫学机制.方法应用形态学方法测定胃癌患者RBC-C3bRR、RBC-ICR及NTER;用ELISA法测定血清TNF-α、IL-6和IL-8含量;用生化方法测定血清NO含量.结果胃癌患者血清NO含量,RBC-C3bRR和NTER明显降低(P均<0.05),术后较术前明显升高(P均<0.05),但仍低于对照组(P均<0.05).血清TNF-α、IL-6、IL-8含量及RBC-ICR明显增高(P均<0.05),术后血清IL-6、IL-8含量及RBC-ICR较术前明显降低(P均<0.05),但仍高于对照组(P均<0.05).胃癌患者TNF-α、IL-6、IL-8间呈正相关,RBC-C3bRR与血清IL-6、IL-8含量呈负相关.结论多项免疫指标的联合检测对揭示胃癌的发病机理、疗效观察和预后判断均有重要的临床意义.
ISSN:1671-8259