Role of leptin and 5-HT2C receptor gene in risperidone-induced obesity / 瘦素和5-HT2C受体基因在利培酮致肥胖中的作用

• Published in: Xi'an jiao tong da xue xue bao. Journal of Xi'an Jiaotong University (medical sciences). Yi xue ban no. 3; p. 332
• Main Authors: ZHANG, Huan, Wan-hu, KANG, Li-yang, GUO, Cheng-ge, GAO, LI, Qiang, Xian-cang, MA, CHEN, Ce, WANG, Wei, FU, Wei, Xiao-bo, YANG
• Format: Journal Article
• Language: Chinese
• Published: Xi'an Xi'an Jiaotong University 01.01.2010
• Subjects: Antipsychotics; Body mass index; Fasting; Glucose; Lipids; Plasma; Polymorphism; Schizophrenia
• ISSN: 1671-8259

Objective: To assess the changes of body weight and biochemical indicators related to metabolic process in subjects with schizophrenia after risperidone therapy and to analyze the association of leptin gene -2548G/A polymorphism and 5-HT2C receptor gene -759C/T polymorphism with the above-mentioned changes. Methods: A total of 123 patients with schizophrenia were treated with risperidone for 10 weeks. Their body weight, waistline and body mass index (BMI) were measured on admission and every 2 weeks subsequently; biochemical indicators including fasting plasma glucose, fasting blood concentration of lipid and leptin were also measured on admission, 4-week and 10-week treatment. The polymorphisms of leptin gene -2548G/A and 5-HT2C receptor gene -759C/T were determined by PCR-RFLP in patients so as to compare these biochemical indicators between different genotypes. Results: After 10 weeks’ risperdone treatment, the patients’ body weight, waistline, BMI and fasting plasma glucose increased significantly (P<0.00