Effects of magnesium sulfate on the serum concentration of interleukin 1β and tumor necrosis factor α in patients with severe traumatic brain injury / 硫酸镁对重型颅脑损伤患者血清IL1β、TNFα浓度的影响

• Published in: Xi'an jiao tong da xue xue bao. Journal of Xi'an Jiaotong University (medical sciences). Yi xue ban no. 4; p. 497
• Main Authors: Bai-xiang, HE, Rui-juan, ZHANG, DING, Li, WANG, Xin, LI, Qi, ZHANG, Zhi-feng, Zhi-chao, WEI
• Format: Journal Article
• Language: Chinese
• Published: Xi'an Xi'an Jiaotong University 01.01.2010
• Subjects: Cytokines; Necrosis; Traumatic brain injury; Tumor necrosis factor-TNF
• ISSN: 1671-8259

Objective: To study the effects of magnesium sulfate on the serum concentration of interleukin 1β (IL1β) and tumor necrosis factor α (TNFα) in patients with severe traumatic brain injury (sTBI) and investigate the mechanism of magnesium ion (Mg2+)’s protective effect on traumatic neurons. Methods: The recruited patients were randomly assigned to experimental group and control group, with 30 cases in each group. Patients in control group were treated by the routine method. Apart from the standardized treatment, patients in experimental group were treated with magnesium sulfate additionally. Normal group consisted of 20 healthy adult donors of blood. We collected elbow venous blood samples at preset time from the subjects, serum levels of Mg2+, IL1β and TNFα were measured by atomic spectrometry and radioimmunoassay, respectively. Then the data were analyzed by SPSS13.0 software package. Results: The serum levels of IL1β and TNFα increased significantly within 24 hours and reached the peak on day 3, then gradual