Synergistic and toxicity-reducing effects of Shenqi injection on 60Co radiotherapy in mice / 参芪注射液对小鼠60Co射线放疗的增效和减毒作用

• Published in: Xi'an jiao tong da xue xue bao. Journal of Xi'an Jiaotong University (medical sciences). Yi xue ban no. 2; p. 249
• Main Authors: Jing-jing, ZHANG, Qing-xia, FAN, Liu-xing, WANG, Rui-tai, FAN, HU, Yong, Dong-li, YUE
• Format: Journal Article
• Language: Chinese
• Published: Xi'an Xi'an Jiaotong University 01.01.2012
• Subjects: Radiation therapy
• ISSN: 1671-8259
• DOI: 10.7652/jdyxb201202029

Objective: To study the synergistic and toxicity-reducing effects of Shenqi injection (SQI) on 60Co radiotherapy in mice. Methods: The tumor-bearing mice models with hepatoma-22 were established. Mice in 60Co group was subjected to 60Co radiotherapy. The joint group was given different doses of SQI by intraperitoneal injection for 7 days in addition to radiation. Then the inhibition rate, the number of white blood cells (WBC), and spleen and thymus indexes were determined. Meanwhile, malonyl dialdehyde (MDA) content and superoxide dismutase (SOD) activity in serum were calculated. Results: Each dose of SQI inhibited the growth of tumor and had synergism with 60Co radiation. Each dose of SQI combined with 60Co increased the number of WBC and spleen index (P<0.01 and P<0.05, respectively). Moreover, the changes of MDA content and SOD activity induced by 60Co were reversed significantly by different doses of SQI, whereas no significant difference was found in thymus index in the joint group. Conclusion: SQI can