The clinical significance of serum level of HMGB1 in severe hepatitis B / 血清高迁移率族蛋白B1在重型乙型病毒性肝炎中的临床意义

• Published in: Xi'an jiao tong da xue xue bao. Journal of Xi'an Jiaotong University (medical sciences). Yi xue ban no. 3; p. 379
• Main Authors: Xiao-jing, LIU, Shu-mei, LIN, Shu-qin, ZHENG, YE, Feng, ZHANG, Xi, DI, Ying, Yue-jiao, LI, ZHANG, Jian
• Format: Journal Article
• Language: Chinese
• Published: Xi'an Xi'an Jiaotong University 01.01.2013
• Subjects: Clinical significance; Hepatitis; Hepatitis B; Infections; Liver diseases; Medical prognosis
• ISSN: 1671-8259
• DOI: 10.7652/jdyxb201303022

Objective: To explore the clinical significance of serum level of high-mobility group box 1 protein (HMGB1) in severe hepatitis B (SHB). Methods: The serum level of HMGB1 was detected by enzyme-linked immunosorbent assay (ELISA) in 70 patients with chronic SHB (CSHB), 70 patients with chronic HBV infection and 35 healthy subjects. The serum level of HMGB1 of 30 patients with CSHB was observed dynamically at three time points, namely, on admission, the 7th and 14th day of admission. The model for end-stage liver disease (MELD) scores of 70 patients with CSHB were calculated according to the 2002 Standard Edition (μmol/L) formula. Results: The serum level of HMGB1(μg/L) in the normal controls, patients with chronic HBV infection, and patients with CSHB was 14.29±4.01, 49.68±7.72, and 61.92±15.42, respectively. Pairwise comparisons among the three groups showed that the serum level of HMGB1 was significantly higher in CSHB patients than in patients with chronic HBV infection and the normal controls (P<0.01); the