Local injection of Icariin on orthodontically induced inflammatory root resorption in rats / 局部注射淫羊藿苷对大鼠正畸致炎性牙根吸收的影响

• Published in: Xi'an jiao tong da xue xue bao. Journal of Xi'an Jiaotong University (medical sciences). Yi xue ban no. 3; p. 400
• Main Authors: Yan-ni, ZHOU, Xue-shun, YUAN, Zi-qi, YUE, Bao-cheng, CAO
• Format: Journal Article
• Language: Chinese
• Published: Xi'an Xi'an Jiaotong University 01.01.2015
• Subjects: Orthodontics
• ISSN: 1671-8259
• DOI: 10.7652/jdyxb201503023

Objective: To study the influence of local administration of Icariin on orthodontically induced inflammatory root resorption (OIIRR). Methods: After rat models of orthodontic root movement were successfully established, rats were injected with 200mg/kg Icariin (Icariin group) or saline (positive control group), respectively. Left maxillary served as the negative control group. The resorption pit of root surface was measured using scanning electron microscopy (SEM), HE staining, and tartrate resistant acid phosphatase (TRAP). Results: The level of TRAP positive cells and root resorption score in Icariin group were significantly lower than those in the positive control group (P<0.05). Each measured value differed significantly between thenegative control group and the positive control group (P<0.05). The level of TRAP positive cells was significantly different (P<0.05), while root resorption scores did not differ between Icariin group and the negative control group (P>0.05). Conclusion: Local administration of