Expression and its clinical significance of ERCC1 in stage Ⅱ colorectal carcinoma / ERCC1在Ⅱ期结直肠癌中的表达及其临床意义
Objective: To investigate the expression and clinical significance of excision repair cross complementing gene 1 (ERCC1) in colorectal carcinoma of stage Ⅱ and its clinical significance. Methods: We collected 56 cases of stage Ⅱ postoperative colorectal carcinoma tissue and detected ERCC1 expression...
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Published in | Xi'an jiao tong da xue xue bao. Journal of Xi'an Jiaotong University (medical sciences). Yi xue ban no. 6; p. 898 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | Chinese |
Published |
Xi'an
Xi'an Jiaotong University
01.01.2017
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Subjects | |
Online Access | Get full text |
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Summary: | Objective: To investigate the expression and clinical significance of excision repair cross complementing gene 1 (ERCC1) in colorectal carcinoma of stage Ⅱ and its clinical significance. Methods: We collected 56 cases of stage Ⅱ postoperative colorectal carcinoma tissue and detected ERCC1 expression with immunofluorescence technique. Statistical analysis was made with SPSS13.0 software. Results: ERCC1 expression was obviously lower in stage II postoperative colorectal carcinoma tissue than in normal tissue (P=0.01). In cancer tissue, ERCC1 expression in patients with relapse or metastasis was significantly lower than in those without (P=0.002); ERCC1 expression in patients with T3 was significantly higher than those with T4 (P=0.044). ERCC1 expression had a positive correlation with the overall survival (OS) and disease-free survival (DFS) (both P=0.000). In the group of high ERCC1 expression patients, five-year OS rate and DFS rate between patients who had received oxaliplatin-based adjuvant chemotherapy a |
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ISSN: | 1671-8259 |
DOI: | 10.7652/jdyxb201706022 |