Accelerating the drug optimization process: Identification, structure elucidation, and quantification of in vivo metabolites using stable isotopes with LC/MSn

Most preclinical leads exhibit poor ADME/PK properties and require optimizing to increase the likelihood of becoming successful pharmaceuticals. As a means of accelerating the evaluation of these leads in vivo, Taylor, Jia, Bush and Dollinger assessed the use of LC/MS with the chemiluminescent-nitro...

Full description

Saved in:
Bibliographic Details
Published inAnalytical chemistry (Washington) Vol. 74; no. 13; p. 3232
Main Authors Taylor, Eric W, Jia, Weiping, Bush, Mark, Dollinger, Gavin D
Format Journal Article
LanguageEnglish
Published Washington American Chemical Society 01.07.2002
Subjects
Chemistry
Nitrogen
Pharmaceuticals
Online AccessGet full text

Cover

More Information
Summary:Most preclinical leads exhibit poor ADME/PK properties and require optimizing to increase the likelihood of becoming successful pharmaceuticals. As a means of accelerating the evaluation of these leads in vivo, Taylor, Jia, Bush and Dollinger assessed the use of LC/MS with the chemiluminescent-nitrogen detector and a stable isotope to identify and quantify in vivo metabolites and to measure excretion.
ISSN:0003-2700
1520-6882