Association of in-stent restenosis with serum Gal-3 and MMP-9 levels / 半乳糖凝集素-3和基质金属蛋白酶-9与支架内再狭窄的关系

• Published in: Xi'an jiao tong da xue xue bao. Journal of Xi'an Jiaotong University (medical sciences). Yi xue ban no. 4; p. 483
• Main Authors: Xiao-ting, NIU, XU, Yang, Yang, ZHENG, Xiao-huan, LIU, GONG, Hong, Ya-jie, FAN, Chun-yan, ZHANG, ZHANG, Yan, Yan-chao, HU, Yong-qin, LI, Cong-xia, WANG
• Format: Journal Article
• Language: Chinese
• Published: Xi'an Xi'an Jiaotong University 01.01.2018
• Subjects: Atherosclerosis; Stents
• ISSN: 1671-8259
• DOI: 10.7652/jdyxb201804008

Objective: To investigate the relationship of galectin-3 (Gal-3) and matrix metalloproteinase-9 (MMP-9) with in-stent restenosis (ISR). Methods: We consecutively recruited 434 patients who had undergone successful drug eluting stent (DES) implantation. Then we divided them into ISR group (n=41) and NO-ISR group (n=393) according to the results of coronary angiography review. Independent risk factors for ISR were found out by multivariate analysis and the two groups were matched for these factors except for Gal-3 and MMP-9. After elimination of the influence of confounders, serum Gal-3 and MMP-9 were compared between the groups and their relations with the severity of ISR were analyzed. Patients were grouped based on Gal-3 and MMP-9 concentrations and major adverse cardiac events (MACEs) were compared between the two groups. Results: After elimination of the influence of confounders, the results showed that serum levels of Gal-3 and MMP-9 were significantly higher in ISR group than in NO-ISR group (P<0.001). S