Reticulated platelets are associated with long-term outcomes of premature coronary artery disease following percutaneous coronary intervention / 网织血小板与早发冠心病PCI术后远期预后的相关性

• Published in: Xi'an jiao tong da xue xue bao. Journal of Xi'an Jiaotong University (medical sciences). Yi xue ban no. 3; p. 327
• Main Authors: ZHANG, Yan, Cong-xia, WANG, Xiao-huan, LIU, Chun-yan, ZHANG, Yan-chao, HU, Wei-dong, MA, JIA Shan, Yong-qin, LI, Zhen-hua, HAN
• Format: Journal Article
• Language: Chinese
• Published: Xi'an Xi'an Jiaotong University 01.01.2018
• Subjects: Angioplasty; Blood platelets; Cardiovascular disease; Coronary vessels; Stents
• ISSN: 1671-8259
• DOI: 10.7652/jdyxb201803006

Objective: To investigate the assocaition between reticulated platelets (RPs) and long-term outcomes of premature coronary artery disease (PCAD) patients after percutaneous coronary intervention (PCI). Methods: We recruited 300 PCAD patients (males aged <45 years and females aged <55 years at the onset of coronary artery disease) and 250 controls with normal coronary angiographic results. RPs percentage was assessed using a direct, whole blood, dual-labeling flow cytometric method. We evaluated the association of RPs with long-term major adverse cardiac events (MACE) after 24-month follow-up and coronary in-stent restenosis (ISR). Results: : There were 20 cardiac events (6.7%) during the 24-month follow-up. PCAD and control groups differed significantly in smoking, diabetes, family history, and history of heart failure. RPs were significantly higher in PCAD group than in control group (P<0.05). The incidence of ISR in RPs>10% group was significantly different from that in RPs 6%-8% group (P<0.05). Cox proport