Pentobarbital-induced place aversion learning

Pentobarbital is self-administered by rats but has also been reported to produce a conditioned place aversion. Since the self-administration and place preference paradigms both are considered to assess drug reward, we further examined the hedonic properties of pentobarbital, using place conditioning...

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Bibliographic Details
Published inLearning & behavior Vol. 26; no. 2; p. 219
Main Authors Lew, Gilbert, Parker, Linda A
Format Journal Article
LanguageEnglish
Published Austin Psychonomic Society, Inc 01.05.1998
Subjects
Animal behavior
Drugs
Learning
Rodents
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Summary:Pentobarbital is self-administered by rats but has also been reported to produce a conditioned place aversion. Since the self-administration and place preference paradigms both are considered to assess drug reward, we further examined the hedonic properties of pentobarbital, using place conditioning. In Experiment 1, a dose of 15 mg/kg (intraperitoneal) of pentobarbital produced a conditioned place aversion after 4 conditioning trials of various durations (5, 15, 30, or 60 min).
ISSN:1543-4494
1543-4508