Overexpressing sperm surface (beta)1,4-galactosyltransferase in transgenic mice affects multiple aspects of sperm-egg interactions

The effect of increasing the levels of sperm surface galactosyltransferase (GalTase) on sperm-egg interactions was examined in transgenic mice that overexpress GalTase under the control of a heterologous promoter. Results indicate that excess surface GalTase is counterproductive to successful sperm-...

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Bibliographic Details
Published inThe Journal of cell biology Vol. 126; no. 6; p. 1573
Main Authors Youakim, Adel, Hathaway, Helen J, Miller, David J, Gong, Xiaohai, Shur, Barry D
Format Journal Article
LanguageEnglish
Published New York Rockefeller University Press 01.09.1994
Subjects
Animal reproduction
Cellular biology
Rodents
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Summary:The effect of increasing the levels of sperm surface galactosyltransferase (GalTase) on sperm-egg interactions was examined in transgenic mice that overexpress GalTase under the control of a heterologous promoter. Results indicate that excess surface GalTase is counterproductive to successful sperm-egg binding.
ISSN:0021-9525
1540-8140