Extracellular Ca(2plus) modulates leukocyte function-associated antigen-I cell surface distribution on T lymphocytes and consequently affects cell adhesion

It is shown that the binding of the calcium ion, but not the magnesium ion, directly correlates with clustering of leukocyte function-associated antigen-1 (LFA-1) molecules at the cell surface of T cells. Weak binding of the calcium ion is associated with a dispersed LFA-1 surface distribution on T...

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Bibliographic Details
Published inThe Journal of cell biology Vol. 124; no. 6; p. 1061
Main Authors van Kooyk, Yvette, Weder, Pauline, Heije, Kees, Figdor, Carl G
Format Journal Article
LanguageEnglish
Published New York Rockefeller University Press 01.03.1994
Subjects
Biochemistry
Calcium
Cellular biology
Lymphatic system
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Summary:It is shown that the binding of the calcium ion, but not the magnesium ion, directly correlates with clustering of leukocyte function-associated antigen-1 (LFA-1) molecules at the cell surface of T cells. Weak binding of the calcium ion is associated with a dispersed LFA-1 surface distribution on T cells.
ISSN:0021-9525
1540-8140